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They have complex nutritional problems and should be distinguished from those with sensitivity to common food proteins such as cow’s milk, egg and peanuts. Diarrhea often worsens after feeding because of malabsorption of necessary nutrients. J La State Med Soc. Orphanet J Rare Dis. The goal of this oral anti-diarrheal treatment is to restore intestinal function so patients can eat and drink normally. June 28, 2018 – Hamden, Connecticut. The information in NORD’s Rare Disease Database is for educational purposes only and is not intended to replace the advice of a physician or other qualified medical professional. Get the latest research information from NIH: https://www.nih.gov/coronavirus (link is external). The disorder is characterized by chronic, severe, watery diarrhea and insufficient absorption (malabsorption) of necessary nutrients due to incomplete development (hypoplasia) and/or degeneration (atrophy) of surface cells of the wall of the small intestine (e.g., hypoplastic villus atrophy, defective brush-border assembly and differentiation). The disorder is usually present at birth and is characterized by profuse watery diarrhea and a swollen abdomen. For most diseases, symptoms will vary from person to person. 2006;1:22. New research and comprehensive resources for patients with microvillus inclusion disease. B. Lippincott Company. Microvillus inclusion disease (MVID) is a disorder of intestinal epithelial differentiation characterized by life-threatening intractable diarrhea. The chance for a child to receive working genes from both parents is 25%. 2004;77:1024-28. Vanessa Research. Last Updated: Jan 18, 2017. www.emedicine.com/ped/topic2845/htm Accessed July 9, 2019. Get the latest public health information from CDC: https://www.coronavirus.gov (link is external) Research Portfolio Online Reporting Tool (RePORT), Online Mendelian Inheritance in Man (OMIM). The risk is the same for males and females. Other treatment is symptomatic and supportive. Individuals may print one hard copy of an individual disease for personal use, provided that content is unmodified and includes NORD’s copyright. Neal: Microvillus Inclusion Disease, what is that? 2016; Jul 1, 311: G142–G155. Dunn CP, Friedmann JC, Prowse O and Greenstein SM. Identification of ion transport defects in microvillus inclusion disease. Infants born with this disorder are often premature. Liver disease and cholestatis can also occur independent of TPN due to the genetic defect in bile duct cells. Microvillus Inclusion Disease. J Pediatr Gastroenterol Nutr. Have a question? Microvillus inclusion disease (congenital microvillus atrophy), although rare, appears to be the most common cause of congenital intractable watery diarrhea. To research the causes of Microvillus Inclusion Disease, consider researching the causes of these these diseases that may be similar, or associated with Microvillus Inclusion Disease: Till date, only a handful of cases with MVID have been described in English literature. [1] [2] Last updated: 10/5/2011. http://www.orpha.net/consor/cgi-bin/Disease_Search.php?lng=EN&data_id=2157&Disease_Disease_Search_diseaseGroup=Microvillus-inclusion-disease&Disease_Disease_Search_diseaseType=Pat&Disease(s)/group%20of%20diseases=Microvillus-inclusion-disease&title=M. What causes the disease and why does it affect infants and does it only affect infants? Ruemmele FM, Jan D, Lacaille F, et al. How can we make GARD better? Nelson Textbook of Pediatrics. 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